The quadruple screen is also called as the quadruple marker test It is performed in women who missed screening test after NT scan and is done between 15 and 21 weeks of gestation when the BPD is between 31 and 52mm. Ultrasound examination is performed prior to test to confirm the gestational age and rule out major congenital anomalies.
In quadruple screening test in Vijayawada, the levels of four substances in pregnant women’s blood- Alpha-fetoprotein (AFP), Human chorionic gonadotropin (HCG), unconjugated estriol, and Inhibin A are analysed and risk for aneuploidy is generated in a software.
This test has a detection rate of 80% at a false positive rate of 5% for Trisomy 21.
Apart from obtaining risk for aneuploidy, quad test provides information regarding risk for open neural tube defect (ONTD)/ abdominal wall defects. Increased levels of AFP in the maternal blood indicates increased risk of ONTD. In cases of increased risk of ONTDD, it is advised to get a detailed ultrasound examination by a fetal medicine consultant to rule out congenital anomalies.
Consult Dr. P. Madhavi Latha who is the fetal medicine specialist at ultrasound scan centers
If you have any questions or need help, feel free to Call Us